Wednesday, July 30, 2014

Wishes for the Fujifilm X200

With photokina right around the corner I have suddenly started shooting a little again. The X100 is still a magnificent camera, but I have some gripes and some hopes and wishes for the next iteration. A lot was improved with the X100S but not enough for me to buy a new camera. However, the Fujifilm X-T1 has many of the asked-for features, which shows that Fujifilm is heading in the right direction. Here is a list of what I would like to see in a new X200 (or whatever they will call it).
Concept for the new X200, very similar to the old X100/X100S but with some new switches.

  1. Continuous shooting with a proper buffer so that it is possible to continue shooting immediately after a short burst. On the Canon EOS1D you could shoot a burst and shoot another burst immediately. Even on the X100S you have to wait interminable seconds even if you only shot a two-picture burst.
  2. Shooting priority shutter release. That is, when the button is pushed all the way down the picture is captured, no waiting for autofocus, no nothing.
  3. Focus tab on the focusing wheel with always-on manual focus that automatically brings up digital split image or peaking. (On the lens focus wheel)
  4. Dedicated shooting-mode switch: Single - Macro - Continuous. Macro is in the middle because if you shoot macro you have the time to be precise when changing mode. (Drawn on the left top edge)
  5. Dedicated ISO-dial that you have to lift to turn to automatic. (Below the shutter release)
  6. Dedicated flash-mode switch. (Behind the flash shoe)
  7. Dedicated film-mode switch (Under the shutter-speed dial) with a lock button that you need to press to change it. A lock button that you also need to press to select A, B, or T on the shutter speed. (On top of the shutter-speed dial)
  8. Dedicated switch for the neutral density filter. (Behind the shutter-speed dial)
  9. Larger menu and arrow buttons, a dedicated back button and a large touch screen.
In short, I would like more manual control with easily visually verifiable settings. Oh, and a faster camera. 
Here is a picture of Madicken and her new friend Vilde captured with the X100.

Wednesday, July 23, 2014

Pathophysiology of cardiorenal syndrome

Am I writing about actual science? Yes, apparently so. Thing is, the American Physiological Society has graciously decided that all corresponding authors of reviews and editorials would get 50 free reprints (useless), or a toll-free link (useful). However, in order to use said link you have to provide a specific URL of origin, wherein lies the problem. I don't trust the university to maintain my homepage anymore seeing as they just closed it down in favour of their new database-based system that I cannot do stuff with. So, this is the post where I will place the link.

The article was an invited review connected to an abstract sent to Experimental Biology 2014 in San Diego. It is basically a walk through of how nervous and hormonal signalling affects kidney function in heart failure and thus contribute to the development of edema, and the worsening of both heart failure and kidney function in a vicious circle.

The title is: Renal neurohormonal regulation in heart failure decompensation, and it was written together with my present students Sofia, Mediha, and Jacqueline who are still in the lab, and Fredrik who have since moved on to his clinical internship.

For the time being you will have to make do with a (non-toll free) link to the article: LINK

Saturday, February 22, 2014

Sketchbook Ink on the iPad

There's a new sketching program for the iPad. Yes, I realise it isn't that new anymore, but it's new for me. The program is Sketchbook Ink from Autodesk, the same company that gave us AutoCad and more important in this case, Sketchbook Pro. It is available for both the iPad and Android.The main difference is that Sketchbook Ink is vector based, which means that you can zoom in as much as you want without loosing resolution or getting a pixelated image.

The tools are quite limited, just a small selection of brushes and erasers. But you can vary the line-weight easily with a slider at the bottom. It is very easy to ink a drawing and the brushes behave well and predictably. Here is one of my old judo drawings which has been inked really quickly. Further, the program handles layers in an admirable way.
The program has some drawbacks, in my book the main missing features are:
  • Vector selection.
  • Filling, ideally including gradients.
  • Export to a vector-based format.
So, what Autodesk has done is create a very nice and simple vector drawing program, and then they have handicapped it by not including access to the very vectors it is based on. That could have been an reasonable choice in order to make the program as simple as possible, if only they had allowed us to export the vectors so that we could work with them in another program. As it stands, Sketchbook Ink is just a toy, and not really worth your time and money.

Sunday, August 11, 2013

Judo techniques - Free to use illustrations

Previously on Nephrophysiologist we looked at some free judo illustrations that our club were potentially going to use for grading hand-outs. The number of illustrations has grown steadily, but the first actual use the pictures have seen is the poster at the top. It isn't half-bad if you ask me, but then I may be biased.

Work-wise the bulk of the time was spent trying to re-size all pictures so that the figures appear to be about the same size. Then a quick levels adjustment to get rid of the slight gradient that Art Rage uses for a background, and a hue/saturation adjustment to make the blue gis blue rather than purple. Finally I had to trace-down the font used for an old club T-shirt. After much searching and many, many pages of fonts a friend of a friend identified it as Grenoble. Then it was easily found at our friendly font repository.
To finish off I would just like to remind everyone that there is a repository of free, as in speech and beer, judo illustrations to be had under the Creative Commons - attribution, share-alike - license on flickr.com and most of them can also be found at the wikimedia commons. This here below is sasae-tsuri-komi-ashi perhaps done best in the history of the world by Muneta Yasuyuki. However, it usually looks more like slow collaborative falling.

Monday, August 05, 2013

Books for anaesthesiology - General textbooks

Having properly started my residency in anaesthesiology and intensive care medicine I have started looking for textbooks to help me.

In my view medicine has four important levels of knowledge: basic science, clinical practice, evidence based medicine, and epidemiology. Clinical practice will be the focus of your general textbook, but each level deserves its own book because the general textbooks are never good enough. For basic science and EBM the demand for detail and precision is much greater, and epidemiology is often ignored completely.

What follows will be a number of book-reviews of books that I have read, which are useful for anaesthesiology residents. If you have any suggestions, please leave a comment.

So far I have these three general anaesthesia books, which I will say something about.

Morgan & Mikhail's Clinical Anesthesiology (2013, 5 ed. edited by John F. Butterworth IV, David C. Mackey and John D. Wasnick), which is actually available in electronic form through the university library. It's an easy read, unless you are easily annoyed by typos and trivial errors. Instead of references it has suggested reading, which is a mix of reviews, book-chapters and original research. To say that it lacks depth is to state the obvious, but it seems to reflect the state of clinical anaesthesia fairly well.

With that I mean that there is sufficiently scarce evidence that the personal opinion and experience of the individual mentor makes huge differences in how and what you are taught. It is a bit annoying, because you spend a couple of weeks with one specialist behind you, until they are confident to let you run things. Then you change to the next specialist, and they basically think you are insane.

Anestesi (2005, 2 ed. edited by Matts Halldin and Sten Lindahl), a swedish textbook, which is helpful for some practices that are more specifically swedish, and it is generally a good book. Not very thick though, so rather basic.

Anestesikompendium (2004, 8 ed. edited by Rainer Dörenberg), the pocket reference produced by the department in Uppsala. It's brilliant for working in Uppsala for obvious reasons, and includes important practical knowledge like which syringes to use for which drugs, and pre- and postoperative guidelines for different operations and different post-op wards at the hospital.

This early in the residency I am in a read and re-read mode for trying to remember and understand the different anaesthetic regimens and why different specialists prefer different ways of doing things, so it is a good thing to have a couple of books to compare. However, in many cases where practice is significantly different between different specialists they give no, or little guidance, which is why I am seriously considering getting a more complete work. Like 500 pages thicker Clinical Anesthesia by Barash and coauthors, or the two-volume over three thousand pages thick Miller's Anesthesia. In addition there are more specific books covering specific subfields of which I will write more later when I have had time to read them.

Sunday, July 28, 2013

Are the exercise recommendations insane?

I try to stay fit. I lift weights. I do crossfit. I do judo, and I still practice at a fairly respectable level. Since I found the training diary Funbeat about two years ago I have been keeping a detailed training diary. Recently I went through my training statistics and came up with some interesting numbers. In the last two years I have trained 262 times for a total of 285h 29min. That comes out to about 23 minutes per day or 164min per week on average.

Now, let us have a look at the exercise recommendations from the World Health Organization, Centers for Disease Control, or the Swedish equivalent Folkhälsoinstitutet. Here follows the text from the WHO, the others are exactly the same.

Adults aged 18–64 should do at least 150 minutes of moderate-intensity aerobic physical activity throughout the week or do at least 75 minutes of vigorous-intensity aerobic physical activity throughout the week or an equivalent combination of moderate- and vigorous-intensity activity. Aerobic activity should be performed in bouts of at least 10 minutes duration. 
For additional health benefits, adults should increase their moderate-intensity aerobic physical activity to 300 minutes per week, or engage in 150 minutes of vigorous-intensity aerobic physical activity per week, or an equivalent combination of moderate- and vigorous-intensity activity. 
Muscle-strengthening activities should be done involving major muscle groups on 2 or more days a week.
We immediately notice that I follow the minimum guidelines of 75 minutes of vigorous-intensity aerobic activity, and two days with muscle-strengthening activities. But we cannot say that I fulfil the guidelines for additional health benefits. On average I do 164 minutes of exercise including strengthening activities. Of course, we might argue that I ride my bike to work, walk the dog, and go shopping so that I easily fulfil the quota. However, the guidelines specify at least ten minutes duration, and in the complete text specify that you should raise your heart rate and break a sweat. Even going as far as specifying that just shopping or walking the dog does not count for most people because the intensity is too low, so that argument does not work.

In the end we must find that I have a hard time keeping up with the guidelines. At the same time, with that activity level I am able to practice judo with our ten to twenty year younger elite and junior players. I am stronger than I ever was, and have as high endurance as I have had since I stopped swimming. For those (like me) who like numbers that means a 170kg dead-lift, a 90kg bench-press and a 124kg back-squat, and endurance-wise a VO2max of around 60ml/(min*kg). Nothing spectacular, but clearly very fit for a 35-year-old nephrophysiologist.

How can we possibly expect our patients, and the public in general to be able to train that much? And, would I actually increase my expected life-span and number of healthy days by more than doubling my training? For breast and colon cancer the guidelines say:

Data indicate that moderate- to vigorous-intensity physical activity performed at least 30–60 minutes per day is needed to see significantly lower risks of these cancers.
60 minutes per day? On average? For enough time to affect cancer mortality? Who the fuck even completed these studies?

Friday, July 26, 2013

Newton's law of cooking chicken

Newton's law of cooling can be used to predict the time of death from the temperature of a corpse and the ambient, which is a silly and boring example. On the other hand, when we are cooking chicken and our better half asks when it will be done (and demands that it be done in a given time), then it becomes an interesting and useful equation. Let us say that it has already cooked for almost an hour, it is around half past seven, and dinner is supposed to be at eight.

The important point is that Newton's law of cooling is equally applicable to cooking because physical law is symmetrical, which means that cooling and heating behaves the same way. The law states that the rate of change of the temperature of an object is proportional to the difference between its own temperature and the ambient, or
dT(t)/dt = -k(T(t)-Tambient)
where T is the temperature of the object, t is time, k is a constant, and Tambient is the ambient temperature. It is a differential equation that solves to 
T(t) = Tambient + (T(0) - Tambient)e-kt
which we can use to calculate the temperature we have to cook the chicken at to be able to serve dinner at eight(-ish). The only problem is that we have to know the constant k which is specific to the particular chicken and filling we have in the oven. Luckily, we used an oven-thermometer, and we kind of remember how long it has cooked already. So, if it took 50 minutes to go from 10°C to 53°C with the oven at 150°C then we can calculate the constant as
k = -1/t ln((T(t)-Tambient) / (T(0)-Tambient))
that is
k = -1/50 * ln((53-150)/(10-150)) = 0.0073 min-1
In turn, we can use this to calculate what temperature we have to use for the chicken to be done in another 30 minutes as
Tambient = (T(t) - T(0)e-kt) / (1 - e-kt
 which gives
Tambient = (80 - 53*e-0.0073*30) / (1 - e-0.0073*30) = 200°C
Luckily, we didn't have to do the calculations by hand because a bigger nerd than us have created a web-app where we just plug in the known values and get the missing one for free.

Finally, here is the money-shot.
Science, because it works bitch.

(Although the higher temperature did burn the skin a little bit, and it would have been jucier if it had cooked at 150°C the whole time.)